Premature ovarian failure - Vibrance Health

Premature Ovarian Failure (POF)

Premature ovarian failure (POF), also known as primary ovarian insufficiency, is a condition where the ovaries stop functioning normally before age 40. It results in diminished ovarian reserve and reduced fertility.

Some key facts about POF:

• It affects roughly 1% of women under age 40.
• The causes are often unknown but can include autoimmune disorders, genetics, chemotherapy treatment, radiotherapy, or infections.
• Main symptoms are irregular periods or missed periods, hot flashes, night sweats, vaginal dryness, and fertility difficulties.
• There is no cure, but hormone therapy can help manage symptoms. Treatment focuses on dealing with impacts like infertility and bone loss.

Women with POF typically have high follicle-stimulating hormone (FSH) blood levels, indicating their ovaries are not responding properly. Doctors may also check anti-ovarian and anti-adrenal antibodies to assess for autoimmune causes.

The condition is diagnosed with blood tests, and possibly genetic testing. The main aim is supporting the woman psychologically and preserving bone and heart health.

Unfortunately, fertility rates are low, around 5-10%. The ovaries may occasionally release an egg, allowing some chance of conception. Options like donor eggs can be explored.

POF requires managing effects like:

• Infertility - As mentioned, donor eggs or embryo adoption may offer possibilities.
• Higher heart disease and osteoporosis risk - Hormone therapy can help protect bone and cardiovascular health. Maintaining good nutrition and exercise habits is also beneficial.
• Psychological impacts - Counseling or support groups can assist women dealing with self-esteem and identity issues.

The ultimate outlook for women with POF varies substantially depending on the cause and management approach. With proper care to address medical and emotional impacts, many can lead healthy and full lives despite the fertility challenges posed by premature ovarian failure. Monitoring health risks and being proactive with treatment are key.

Visit Vibrance Health for more information on premature ovarian failure and other hormone-related conditions.